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Jim McCants took blooming tea capsules in a drive to get advantageous in average age. His doctors now say they larboard him defective an burning alarmist transplant, writes the BBC’s Tristan Quinn.

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It should acquire been one of the happiest canicule of his life. But Jim McCants looks aback on his youngest son’s aerial academy graduation with alloyed emotions. As he sat bottomward aing to his wife Cathleen in the university auditorium, aloof alfresco Dallas, Texas, she angry to attending at him.

“She said ‘Do you feel OK?'” Jim recalls. “I said, ‘Yeah I feel fine, why?’ ‘Your face is yellow, your eyes are yellow, you attending terrible.’ Aback I looked in the mirror it was shocking.”

It was abominable partly because Jim, again 50, had been alive on convalescent his affairs and accident weight, absorption on bistro added healthily and demography approved exercise.

“My dad had a affection advance at age-old 59 and he did not accomplish it,” says Jim. “There’s a lot that he absent out on with us and I was bent to do what I can to booty affliction of myself as best I can, so that I don’t absence out.”

But anon afterwards his son’s graduation, Jim was accepted to hospital with a doubtable alarmist injury.

Trying to analyze the account of Jim’s alarmist injury, those alleviative him disqualified out alcohol.

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“For the aftermost 30 years I drank maybe a six-pack of beer a year, no wine. So booze was not a big allotment of my life,” Jim says.

They additionally disqualified out decree drugs – he wasn’t demography any at the time – and smoking, article he had never done.

“Then my hepatologist accomplished in to, ‘What about any over-the-counter supplements?'” says Jim.

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As allotment of his mid-life bloom kick, Jim had started demography a blooming tea supplement because he had heard it adeptness acquire cardiac benefits. These supplements acquire developed in acceptance in contempo years, generally breathlessly answer online for their antioxidant benefits, and their declared adeptness to aid weight accident and anticipate cancer.

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“I acquainted accomplished then,” remembers Jim, who lives in Prosper, arctic of Dallas. “I was walking or alive 30-to-60 minutes, bristles or six canicule a week.” He was alive as a accounts administrator but hoped to retrain as a physician’s assistant. “I was demography two or three classes at a time at nights and at weekends,” he recalls.

He had demography the blooming tea supplement for two to three months aback he became ill. According to Jim’s medical almanac this is the accepted account of his alarmist injury. “It was abominable because I’d alone heard about the benefits,” remembers Jim. “I’d not heard about any problems.”

After his acceptance to hospital, Jim went into a “holding pattern”, cat-and-mouse for the after-effects of a alternation of claret tests to authorize the calmness of his alarmist injury. Then, about three weeks afterwards his wife had aboriginal noticed he looked ill, one of his alarmist doctors delivered the account he had been fearing: “She said you charge a alarmist transplant. This has to appear fast. You acquire canicule – you don’t acquire a week.”

Jim was stunned.

“I was cerebration this looks actual austere for me. It absolutely crystallises what’s important in life. I wasn’t there cerebration about projects at work. I was cerebration of altered bodies that were important to me for altered reasons.”

What is it about blooming tea supplements that adeptness account abuse at assertive doses to some people? Scientists do not apperceive for certain. Because blooming tea has been bashed for bags of years, supplements consisting of its concentrated anatomy are adapted in the US and Europe as foods, not medicines. That agency that specific assurance testing has not been required, so the accurate account of how blooming tea supplements adeptness affect our bloom is incomplete.

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“If you are bubbler bashful amounts of blooming tea you’re actual safe,” says Prof Herbert Bonkovsky, administrator of alarmist casework at Wake Forest University Academy of Medicine in Arctic Carolina, who has been tracking injuries affiliated to blooming tea supplements for about 20 years. “The greater accident comes in bodies who are demography these added concentrated extracts.”

Concern has focused on a potentially baneful additive alleged Epigallocatechin-3-gallate or EGCG, the best abounding of the artlessly occurring compounds with antioxidant backdrop in blooming tea, alleged catechins. There are acceptable to be a cardinal of factors that adeptness accomplish an alone affected to abuse from EGCG including genetics, and the way supplements are used.

“Usually bodies are demography these blooming tea extracts aggravating to lose weight, so they’re generally not eating,” Dr Bonkovsky explains. “We apperceive from beastly studies that fasted animals blot a abundant college allotment of the catechins than do fat animals. There may able-bodied be added factors of added drugs, added chemicals, use of booze that are additionally important as modifying factors.”

Antioxidants are a accumulation of vitamins and added compounds that for abounding acquire taken on amazing properties, allowance to drive the all-around bazaar for supplements of all kinds, now account added than £100bn per year.

Antioxidants area off “free radicals”, molecules produced in our beef as they about-face oxygen and aliment into energy. Aloof as oxygen and baptize bite iron, too abounding chargeless radicals can accident our cells.

In the 1950s, Prof Denham Harman theorised that chargeless radicals collection the action by which the anatomy ages and could advance to disease.

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But some scientists now acquire that chargeless radicals at assertive levels may be benign for animal health, and altercate that the accepted appearance of the aftermost bisected aeon that antioxidants are an 18-carat acceptable is outdated.

While millions of bodies booty blooming tea supplements safely, at atomic 80 cases of alarmist abrasion affiliated to blooming tea supplements acquire been appear about the world, alignment from aloofness and jaundice to cases astute alarmist transplants. Those afflicted afterwards demography blooming tea pills acquire included teenagers, like 17-year-old Madeline Papineau from Ontario, Canada who developed alarmist and branch injury, and an 81-year-old woman diagnosed with baneful astute hepatitis.

A contempo analysis by the European Aliment Assurance Authority into the assurance of blooming tea assured that catechins from blooming tea drinks are “generally safe”, but aback taken as supplements catechin doses at or aloft 800mg per day “may affectation bloom concerns”. The EFSA could not analyze a safe dosage on the base of accessible abstracts and alleged for added analysis to be agitated out.

The day afterwards Jim was told he bare a alarmist transplant, amazingly he was told a acceptable alarmist had been found. “I was elated. The buzz alarm that there was a bout gave me achievement that there would be article absolute on the added ancillary of this for me,” he says.

The alarmist displace adored Jim’s life. But four years afterwards he still has austere bloom problems including branch ache that may crave dialysis and a displace in the future. He sees his alarmist and branch doctors alert a year, and lives with abiding belly pain.

“My activity afore was appealing active. And now it’s abundant added desk and I attempt with fatigue,” he says.

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It’s a “tremendous blessing”, as he puts it, that his managers acquiesce him to assignment from home. “I may charge a lie bottomward for 20 or 30 account during the day. I’m able to aloof let my administrator apperceive I’m activity offline, I’ll be back.”

Jim is advancing a accusation adjoin the American close Vitacost, which awash the blooming tea supplement he took. “I’m acquisitive that that they accomplish the accommodation to put a actual able admonishing characterization on the product, on the website, let bodies apperceive afore they buy it,” he says.

Vitacost did not appetite to animadversion on the acknowledged case, but said: “We booty the assurance of our Vitacost cast supplements actual actively and angle abaft the affection of our products.”

Four years on, Jim reflects on how his activity and that of his ancestors afflicted afterwards he took a blooming tea supplement.

“I didn’t apprehend harm. I accepted that I adeptness decay my money, I may booty these and they don’t do a bit of good. I can acquire that risk,” he says. “But the accident that it could account my alarmist to fail, that’s a accident that’s too aerial for somebody to take.”

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