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Persons with bipolar disorders accept aerial ante of comorbid actuality use disorders, abnormally booze dependence. Currently accustomed treatments for booze assurance accept not been advised systematically in this comorbid population.

We address after-effects of an open-label pilot abstraction of add-on acamprosate in individuals with cooccurring bipolar ataxia and booze assurance accepting a abiding dosage of mood-stabilizing medication(s).

Nine men and women who met DSM-IV belief for booze assurance and bipolar ataxia I or II were randomized to accept either 1998 mg/d of acamprosate additional mood-stabilizing medication or mood-stabilizing medication alone. Booze burning and appetite and affection affection were evaluated account for 8 weeks application connected instruments. Blood chemistries were adjourned at baseline and abstraction conclusion.

At abstraction end point, acamprosate-treated capacity appear a decidedly greater abridgement in drinks per anniversary about to baseline as compared with the nontreatment group. Affection array did not alter amid groups at any abstraction time points. Acamprosate was able-bodied tolerated, with no college accident of adverse contest in acamprosate-treated capacity about to controls. No austere adverse contest were reported.

Acamprosate seems to be safe and able-bodied acceptable in individuals with bipolar ataxia and comorbid booze dependence, and may accept ability in abbreviation booze burning in this population. A beyond double-blind, placebo-controlled abstraction of acamprosate in bipolar individuals is warranted.

Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC

Reprints: Bryan K. Tolliver, MD, PhD, Division of Clinical Neuroscience, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC 29425 (e-mail: [email protected]).

Supported by the National Institute on Drug Abuse K24 DA00435 (Kathleen T. Brady).

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