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ESMO Abstract #

Avelumab: LBA6_PR, 659P, 1290P, 1291P, 1282P, 877P; M7824 (TGF β-trap/anti-PD-L1):1048O, 1463P, 1931P, 757P, 643P, 642P, 661P; tepotinib (MET kinase inhibitor): 1377O, 621PD, 698P; M6620: 1437P; M3814: 1845P; M7583: 1014PD; abituzumab: 487P; ErbituxR(cetuximab): 124P, 484P, 509P, 493P, 521P, 510P, 481P, 486P, 1057P, 1108P, 1068P, 1064P, 1293P

Merck, a arch science and technology company, today appear that new abstracts from a array of acute analytic development programs will be presented at the ESMO 2018 Assembly (European Society for Medical Oncology Annual Meeting), October 19-23, 2018, Munich, Germany.

In the year that Merck celebrates its 350-year anniversary, abstracts at the assembly represent a aggregation almanac with eight ameliorative agents beyond 14 bump types, reinforcing Merck’s position at the beginning of analytic development in oncology.

“Our abstracts at this year’s European Society for Medical Oncology Assembly aggrandize our compassionate of avelumab in renal corpuscle blight and added tumors, and authenticate the advance we are authoritative with our pipeline, including bifunctional immunotherapy M7824 and tepotinib,” said Luciano Rossetti, All-around Arch of Analysis & Development for the Biopharma business of Merck. “We attending avant-garde to abounding added years of absolute and cogent advance appear our eyes of transforming the administration and assay of cancer.”

Data from the Appearance III abstraction JAVELIN Renal 101, evaluating avelumab* in aggregate with axitinib, compared with sunitinib as antecedent assay for patients with avant-garde renal corpuscle blight (RCC), will be presented for the aboriginal time during the Presidential Symposium at ESMO on Sunday, October 21, 2018 at 5:20 PM – 5:35 PM CEST. Avelumab is actuality accordingly developed and commercialized with Pfizer. The after-effects represent the aboriginal absolute Appearance III immunotherapy balloon in aggregate with a tyrosine kinase inhibitor (TKI) in any bump type, acknowledging Merck’s absorption in the abeyant use of avelumab in aggregate with currently accustomed therapies and atypical agents. These after-effects will be submitted for advertisement in a peer-reviewed journal. Added updates accommodate new avelumab abstracts in Merkel corpuscle blight (MCC) and avant-garde belly or gastroesophageal accord (GEJ) cancer.

New abstracts for M7824 will be presented from amplification cohorts of two advancing Appearance I analytic trials, including the aboriginal tumor-specific abstracts for squamous corpuscle blight of the arch and close (SCCHN), biliary amplitude cancer, esophageal squamous corpuscle blight and esophageal adenocarcinoma. In addition, adapted abstracts for M7824 in patients with belly blight and non-small corpuscle lung blight (NSCLC) will be shared. M7824, apparent centralized at Merck, is an investigational bifunctional immunotherapy advised to amalgamate a transforming advance agency β (TGF-β) allurement by ‘fusing’ it with the anti-programmed afterlife ligand-1 (PD-L1) mechanism. To date added than 650 patients with assorted types of solid tumors accept been advised beyond the affairs with M7824 and the assurance contour is constant with that empiric with added PD-1/PD-L1 inhibitors and ahead declared bark lesions (keratoacanthomas, SCC, hyperkeratosis) associated with TGF-β-inhibiting therapies.

Data for tepotinib** accommodate after-effects from three Appearance II trials in epidermal advance agency receptor (EGFR) TKI-resistant NSCLC and avant-garde hepatocellular carcinoma, accouterment added affirmation of this attention medicine’s abeyant analytic activity in a ambit of tumors. Tepotinib, apparent centralized at Merck, is an investigational, articulate MET inhibitor that is advised to selectively arrest the oncogenic MET receptor signaling acquired by MET (gene) alterations or MET protein overexpression.

Additional activity abstracts affection adapted abstracts from Merck’s absolute DNA accident acknowledgment (DDR) portfolio. These accommodate after-effects from a Appearance I balloon investigating M6620 (formerly VX-970) in aggregate with gemcitabine in patients with avant-garde NSCLC, and accumulated abstracts from two Appearance I trials of DNA-dependent protein kinase inhibitor, M3814. After-effects will additionally be aggregate from a Appearance I/II balloon of M7583, a Bruton’s TKI, in patients with B-cell malignancies, as able-bodied as a attendant assay of the Appearance I/II Poseidon abstraction investigating abituzumab in patients with metastatic colorectal blight (mCRC).

a, b Time from US Food and Drug Administration approval to ..
a, b Time from US Food and Drug Administration approval to .. | sunitinib fda label

Data to be presented at the assembly for ErbituxR will add to the growing anatomy of real-world affirmation acknowledging the therapy’s role as a accustomed of affliction in RAS wild-type mCRC and first-line alternate or metastatic SCCHN (R/M SCCHN), and for patients with locally avant-garde SCCHN (LA SCCHN) who may not be able to abide cisplatin-based regimens in full.

*Avelumab is beneath analytic assay for the assay of RCC, MCC, CRC, belly and GEJ cancer, and has not been accustomed to be safe and able for these indications. There is no acceding that avelumab will be accustomed for RCC, CRC, belly or GEJ blight by any bloom ascendancy worldwide.

**Tepotinib is the recommended International Nonproprietary Name (INN) for the MET kinase inhibitor MSC2156119J. Tepotinib is currently beneath analytic assay and not accustomed for any use anywhere in the world.

Tepotinib, M7824, M3814, M7583, M6620 and abituzumab are beneath analytic assay and accept not been accurate to be safe and effective. There is no acceding any artefact will be accustomed in the accustomed adumbration by any bloom ascendancy worldwide.

Notes to Editors

Key Merck-supported abstracts slated for presentation are listed below. In addition, a cardinal of investigator-sponsored studies accept been accustomed (not listed).

Title Advance Author Abstract # Presentation Location Date / Time (CEST) Avelumab Late-Breaking Abstracts JAVELIN Renal 101: R Motzer LBA6_PR Sun, Oct 21, Hall A2 – a randomized, 4:30 – 6:10 PM Room 18 appearance 3 abstraction of (5:20 – 5:35 PM avelumab address time) axitinib vs sunitinib as first-line assay of avant-garde renal corpuscle blight (aRCC) Poster Sessions Avelumab T Doi 659P Sun, Oct 21 Hall A3 – (anti-PD-L1) in 12:45 – 1:45 PM Poster Area Japanese patients Networking Hub with avant-garde belly or gastroesophageal accord blight (GC/GEJC): adapted after-effects from the appearance 1b JAVELIN Solid Bump JPN balloon Avelumab in P Nathan 1290P Sun, Oct 21, Hall A3 – European patients 12:45 – 1:45 PM Poster Area (pts) with Networking Hub metastatic Merkel corpuscle blight (mMCC): acquaintance from an ad hoc broadcast admission affairs (EAP) Cost-effectiveness M Bharmal 1291P Sun, Oct 21, Hall A3 – (CE) of avelumab 12:45 – 1:45 PM Poster Area vs accustomed affliction Networking Hub (SC) for the assay of patients (pts) with metastatic Merkel corpuscle blight (mMCC) Responder assay SP D’Angelo 1282P Sun, Oct 21, Hall A3 – based on 12:45 – 1:45 PM Poster Area patient-reported Networking Hub outcomes (PROs) and analytic endpoints (CEPs) in patients (pts) with metastatic Merkel corpuscle blight (mMCC) advised with avelumab First-line (1L) or UN Mon, Oct 22, Hall A3 – second-line (2L) Vaishampayan 877P 12:45 – 1:45 PM Poster Area avelumab Networking Hub monotherapy in patients (pts) with avant-garde renal corpuscle blight (aRCC) enrolled in the appearance 1b JAVELIN Solid Bump balloon

Title Advance Author Abstract # Presentation Location Date / Time (CEST M7824 (TGF β-trap/anti-PD-L1) Proffered Paper Affair M7824 BC Cho 1048O Mon, Oct 22, ICM, Room (MSB0011359C), a 2:45 – 4:15 PM 14B bifunctional (3:00 PM admixture protein address time) targeting PD-L1 and TGF-β, in patients (pts) with avant-garde SCCHN: after-effects from a appearance 1 accomplice Poster Sessions Adapted after-effects of L Paz-Ares 1463P Sat, Oct 20, Hall A3 – M7824 12:30 – 1:30 PM Poster Area (MSB0011359C), a Networking Hub bifunctional admixture protein targeting TGF-β and PD-L1, in second-line (2L) NSCLC Assessment of PD1/ T Mrowiec 1931P Sun, Oct 21, Hall A3 – PD-L1 12:45 – 1:45 PM Poster Area colocalization in Networking Hub hepatocellular blight (HCC) application brightfield bifold labeling and quantitative agenda angel assay M7824 C Yoo 757P Sun, Oct 21, Hall A3 – (MSB0011359C), a 12:45 – 1:45 PM Poster Area bifunctional Networking Hub admixture protein targeting PD-L1 and TGF-β, in Asian patients with pretreated biliary amplitude cancer: basic after-effects from a appearance 1 balloon M7824 B Tan 643P Sun, Oct 21, Hall A3 – (MSB0011359C), a 12:45 – 1:45 PM Poster Area bifunctional Networking Hub admixture protein targeting PD-L1 and TGF-β, in patients with post-platinum esophageal adenocarcinoma (EAC): basic after-effects from a appearance 1 accomplice Appearance 1 abstraction CC Lin 642P Sun, Oct 21, Hall A3 – after-effects from an 12:45 – 1:45 PM Poster Area esophageal Networking Hub squamous corpuscle blight (ESCC) accomplice advised with M7824 (MSB0011359C), a bifunctional admixture protein targeting transforming advance agency β (TGF-β) and PD-L1 Adapted after-effects YJ Bang 661P Sun, Oct 21, Hall A3 – from a appearance 1 12:45 – 1:45 PM Poster Area balloon of M7824 Networking Hub (MSB0011359C), a bifunctional admixture protein targeting PD-L1 and TGF-β, in patients with pretreated alternate or adverse belly blight

Title Advance Author Abstract # Presentation Location Date / Time (CEST) Tepotinib Proffered Paper Affair Appearance 2 abstraction of YL Wu 1377O Fri, Oct 19, Hall A2, tepotinib 4:00 – 5:30 PM Room 18 gefitinib (4:51 PM (TEP GEF) in address time) MET-positive (MET )/epidermal advance agency receptor (EGFR)-mutant (MT) non-small lung blight (NSCLC) Poster Discussion Appearance 2 balloon of BY Ryoo 621PD Fri, Oct 19, Hall B3, tepotinib vs 3:45 – 5:30 PM Room 21 sorafenib in Asian (4:25 PM patients (pts) address time) with avant-garde hepatocellular blight (HCC) Poster Affair Appearance 2 adeptness T Decaens 698P Sun, Oct 21, Hall A3 – and assurance abstracts 12:45 – 1:45 PM Poster Area for the MET Networking Hub inhibitor tepotinib in patients (pts) with sorafenib-treated avant-garde hepatocellular blight (HCC)

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Title Advance Author Abstract # Presentation Location Date / Time (CEST) M6620 Poster Affair Appearance I dosage R Plummer 1437P Sat, Oct 20, Hall A3 – amplification abstracts for 12:30 – 1:30 PM Poster Area M6620 (formerly Networking Hub VX-970), a first-in-class ATR inhibitor, accumulated with gemcitabine (Gem) in patients (pts) with avant-garde non-small corpuscle lung blight (NSCLC)

Title Advance Author Abstract # Presentation Location Date / Time (CEST) M3814 Poster Affair Safety, analytic M Mau-Sorensen 1845P Sat, Oct 20, Hall A3 – activity and 12:30 – 1:30 PM Poster Area pharmacological Networking Hub biomarker appraisal of the DNA-dependent protein kinase (DNAPK) inhibitor M3814: after-effects from two appearance I trials

Title Advance Author Abstract # Presentation Location Date / Time (CEST) M7583 Poster Affair Appearance I/II, aboriginal W Jurczak 1014PD Sun, Oct 21, Hall B3 – in animal balloon 4:30 – 5:45 PM Room 21 with M7583, a Bruton’s tyrosine kinase inhibitor (BTKi), in patients with B corpuscle malignancies

Title Advance Author Abstract # Presentation Location Date / Time (CEST) Abituzumab Poster affair Accommodating alternative R Laeufle 487P Sun, Oct 21, Hall A3 – for targeting 12:45 – 1:45 PM Poster Area integrin with Networking Hub abituzumab in patients with metastatic colorectal blight (mCRC). A attendant assay of the randomized appearance I/II Poseidon abstraction

Title Advance Author Abstract # Presentation Location Date / Time (CEST) Erbitux Poster Sessions Association of L Miller-Phillips 124P Sat, Oct 20, Hall A3 – microRNA-21 12:30 – 1:30 PM Poster Area (miR-21) with Networking Hub adeptness of cetuximab (cet) and bevacizumab (bev) in patients with metastatic colorectal blight (mCRC) aural the FIRE-3 abstraction (AIO KRK-0306) Attendant RAS A Sobrero 484P Sun, Oct 21, Hall A3 – assay of the 12:45 – 1:45 PM Poster Area EPIC trial: Networking Hub Cetuximab additional irinotecan adjoin irinotecan abandoned in patients with third- and further-line metastatic colorectal blight Factors DP Modest 509P Sun, Oct 21, Hall A3 – influencing 12:45 – 1:45 PM Poster Area about-face to Networking Hub resectability and adaptation afterwards resection of metastases in RAS WT metastatic colorectal blight (mCRC): assay of FIRE-3- AIOKRK0306 Antecedent address of E Oki 493P Sun, Oct 21, Hall A3 – a appearance I/II abstraction 12:45 – 1:45 PM Poster Area of S-1 and Networking Hub irinotecan (IRIS) in aggregate with cetuximab in patients with wild-type (wt) RAS metastatic colorectal blight miR-31 as a Y Gaston-Mathe’ 521P Sun, Oct 21, Hall A3 – anxiety and 12:45 – 1:45 PM Poster Area predictive cast Networking Hub of advantageous adaptation (DFS) in resected date III colon cancer: a attendant assay of the PETACC-8 balloon Targeted therapies BC Xing 510P Sun, Oct 21, Hall A3 – in about-face 12:45 – 1:45 PM Poster Area assay in mCRC: A Networking Hub analytical assay and meta-analysis Appearance II abstraction of H Osawa 481P Sun, Oct 21, Hall A3 – cetuximab 12:45 – 1:45 PM Poster Area rechallenge in Networking Hub patients with RAS wild-type metastatic colorectal cancer: E-rechallenge balloon -to-be X Garcia-Albe’niz 486P Sun, Oct 21, Hall A3 – biomarker abstraction in 12:45 – 1:45 PM Poster Area avant-garde RAS Networking Hub wild-type colorectal cancer. POSIBA trial. (GEMCAD 10-02) Cetuximab C Le Tourneau 1057P Sun, Oct 21, Hall A3 – platinum-based 12:45 – 1:45 PM Poster Area assay (PBT) as a Networking Hub first-line assay for patients with recurrent/metastat ic squamous corpuscle blight of the arch and close (R/M SCCHN): an empiric abstraction (ENCORE) Can accessory J Dunst 1108P Sun, Oct 21, Hall A3 – diseases adumbrate 12:45 – 1:45 PM Poster Area the acquiescence Networking Hub with cisplatin additional RT in patients with locally avant-garde squamous corpuscle blight of the arch and close (LA SCCHN)? An basic endpoint assay of the COMPLY balloon Cetuximab in JC Ham 1068P Sun, Oct 21, Hall A3 – aggregate with 12:45 – 1:45 PM Poster Area methotrexate (MTX) Networking Hub as first-line assay in alternate or metastatic (R/M) squamous corpuscle blight of the arch and close (SCCHN), a appearance Ib – randomized appearance II abstraction adjoin audible abettor MTX Cetuximab in M Hecht 1064P Sun, Oct 21, Hall A3 – aggregate with 12:45 – 1:45 PM Poster Area platinum-based Networking Hub chemotherapy or radiotherapy in patients with alternate and/or metastatic SSCHN in analytic routine: Adapted acting after-effects of the -to-be SOCCER abstraction Cetuximab in F Peyrade 1293P Sun, Oct 21, Hall A3 – patients with 12:45 – 1:45 PM Poster Area unresectable Networking Hu cutaneous squamous corpuscle blight is safe and able – A real-life assay

About Avelumab

Avelumab is a animal anti-programmed afterlife ligand-1 (PD-L1) antibody. Avelumab has been apparent in preclinical models to appoint both the adaptive and congenital allowed functions. By blocking the alternation of PD-L1 with PD-1 receptors, avelumab has been apparent to absolution the aishment of the T cell-mediated antitumor allowed acknowledgment in preclinical models.[1]-[3] Avelumab has additionally been apparent to abet NK cell-mediated absolute bump corpuscle lysis via antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro.[3]-[5] In November 2014, Merck and Pfizer appear a cardinal accord to co-develop and co-commercialize avelumab.

Avelumab is currently actuality evaluated in the JAVELIN analytic development program, which involves at atomic 30 analytic programs, including seven Appearance III trials, and added than 8,600 patients beyond added than 15 altered bump types. For a absolute account of all avelumab trials, amuse appointment clinicaltrials.gov.

Approved Breach in the US

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The US Food and Drug Administration (FDA) accepted accelerated approval for avelumab (BAVENCIOR) for the assay of (i) adults and pediatric patients 12 years and earlier with metastatic Merkel corpuscle blight (mMCC) and (ii) patients with locally avant-garde or metastatic urothelial blight (mUC) who accept ache progression during or afterward platinum-containing chemotherapy, or accept ache progression aural 12 months of neoadjuvant or accessory assay with platinum-containing chemotherapy. These breach are accustomed beneath accelerated approval based on bump acknowledgment amount and continuance of response. Continued approval for these breach may be accidental aloft analysis and description of analytic account in acknowledging trials.

Important Assurance Information from the US FDA Accustomed Label

The warnings and precautions for BAVENCIO accommodate immune-mediated adverse reactions (such as pneumonitis, hepatitis, colitis, endocrinopathies, nephritis and renal dysfunction, and added adverse reactions), infusion-related reactions and embryo-fetal toxicity.

Common adverse reactions (reported in at atomic 20% of patients) in patients advised with BAVENCIO for mMCC and patients with locally avant-garde or mUC accommodate fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reaction, borderline edema, decreased appetite/hypophagia, urinary amplitude infection and rash.

About M7824

M7824 is an investigational bifunctional immunotherapy that is advised to accompany calm a TGF-β allurement and ‘fuse’ it with the anti-PD-L1 mechanism. M7824 is advised to accompanying block the two immunosuppressive pathways – targeting both pathways aims to ascendancy bump advance by potentially abating and acceptable anti-tumor responses. M7824 is currently in Appearance I studies for solid tumors.

About Tepotinib

Tepotinib (MSC2156119J) is an investigational, articulate MET inhibitor that is anticipation to arrest oncogenic MET receptor signaling acquired by MET (gene) alterations, including both MET exon 14 absence mutations and MET amplifications, or MET protein overexpression. It is a attention anesthetic and is advised to accept a awful careful apparatus of action.

About M6620

Practical updates in medical therapy for advanced and metastatic ..
Practical updates in medical therapy for advanced and metastatic .. | sunitinib fda label

M6620 (previously accepted as VX-970) is an investigational small-molecule anticipation to arrest anarchy telangiectasia and Rad3-related protein (ATR). ATR is believed to be a key sensor for DNA damage, activating the DNA accident checkpoint and arch to corpuscle aeon arrest. Inhibition of ATR could potentially enhance the adeptness of DNA-damaging agents, but is additionally actuality advised as a monotherapy adjoin tumors with aerial levels of archetype accent induced by overexpression of oncogenes.

About M3814

M3814 is an investigational small-molecule which is anticipation to arrest DNA-dependent protein kinase (DNA-PK). DNA-PK is a key agitator for non-logous end-joining (NHEJ), an important DNA double-strand breach (DSB) adjustment pathway. Analytic studies investigating combinations of M3814 with added frequently acclimated DNA-damaging agents such as radiotherapy and chemotherapy are underway.

About M7583

M7583 is an investigational assay that is anticipation to be a awful careful covalent inhibitor of Bruton’s tyrosine kinase (BTKi) advised to abbreviate astray effects.

About Abituzumab

Abituzumab is an investigational pan-αν integrin inhibiting monoclonal antibiotic anticipation to appearance activity adjoin αvβ1, 3, 5, 6 and 8 integrin heterodimers. Merck entered into a development acceding with the SFJ Pharmaceuticals Accumulation for abituzumab in metastatic colorectal blight (mCRC). This accord will acquiesce Merck and SFJ to advance the abeyant of abituzumab in a targeted way, absorption on a accommodating citizenry that may account from the assay the most.

About ErbituxR (cetuximab)

ErbituxR is a IgG1 monoclonal antibiotic targeting the epidermal advance agency receptor (EGFR). As a monoclonal antibody, the approach of activity of Erbitux is audible from accustomed non-selective chemotherapy treatments in that it accurately targets and binds to the EGFR. This bounden inhibits the activation of the receptor and the consecutive signal-transduction pathway, which after-effects in abbreviation both the aggression of accustomed tissues by bump beef and the advance of tumors to new sites. It is additionally believed to arrest the adeptness of bump beef to adjustment the accident acquired by chemotherapy and radiotherapy and to arrest the accumulation of new claret argosy central tumors, which appears to advance to an all-embracing aishment of bump growth. Based on in vitro evidence, Erbitux additionally targets cytotoxic allowed effector beef appear EGFR cogent bump beef (antibody abased cell-mediated cytotoxicity, ADCC).

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The best frequently appear ancillary aftereffect with Erbitux is an acne-like bark rash. In about 5% of patients, hypersensitivity reactions may action during assay with Erbitux; about bisected of these reactions are severe.

Erbitux has already acquired bazaar allotment in over 100 countries all-embracing for the assay of RAS wild-type metastatic colorectal blight and for the assay of squamous corpuscle blight of the arch and close (SCCHN). Merck accountant the appropriate to bazaar Erbitux, a registered cast of ImClone LLC, alfresco the U.S. and Canada from ImClone LLC, a wholly-owned accessory of Eli Lilly and Company, in 1998.

All Merck Press Releases are broadcast by e-mail at the aforementioned time they become accessible on the Merck Website. Amuse go to http://www.merckgroup.com/subscribe to annals online, change your alternative or abandon this service.

About Merck

Merck is a arch science and technology aggregation in healthcare, activity science and achievement materials. Almost 53,000 advisers assignment to added advance technologies that advance and enhance activity – from biopharmaceutical therapies to amusement blight or assorted sclerosis, cutting-edge systems for accurate analysis and production, to aqueous crystals for smartphones and LCD televisions. In 2017, Merck generated sales of € 15.3 billion in 66 countries.

Founded in 1668, Merck is the world’s oldest biologic and actinic company. The founding ancestors charcoal the majority buyer of the about listed accumulated group. Merck holds the all-around rights to the Merck name and brand. The alone exceptions are the United States and Canada, area the aggregation operates as EMD Serono, MilliporeSigma and EMD Achievement Materials.

References

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